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Scale-up of a Biopharmaceutical Chromatography Column

Scale-up of a Biopharmaceutical Chromatography Column

A great many drug production processes rely on chromatography, which is a method used for separating chemical components – in this case monoclonal antibodies – which are a specific class of proteins used throughout the pharmaceutical industry.  Chromatography works by passing liquid from a cell culture (analyte, or mobile phase) through a column (see Figure 1).  The column is typically packed with small porous particles (media, or stationary phase) that have more affinity f...
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Improved Air Pollutant Removal at Genesee Generating Station

Improved Air Pollutant Removal at Genesee Generating Station

Genesee Generating Station is a coal fired station jointly owned by Capital Power  and TransAlta , located near Genesee, Alberta, Canada, about eighty kilometers southwest of Edmonton. Two Spray Dryer Absorbers (SDA) on Unit 3 are designed to remove Sulfur Dioxide from the flue gas stream.  Atomizers eject droplets of lime slurry, which evaporate while the solid particulates react with the Sulfur Dioxide in the flue gas to form Calcium Sulfate, which is then captured in a downstream fa...
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Flying Sturgeon? EPRI and Alden Evaluate the Passage of an Ancient Fish through The Whooshh Fish Cannon

Flying Sturgeon? EPRI and Alden Evaluate the Passage of an Ancient Fish through The Whooshh Fish Cannon

What happens when a fish that was swimming in our rivers at the same time dinosaurs were roaming the earth meets a fish passage technology developed within the last several years?  The answer is successful transport of an ancient species through a semi-rigid tube that uses a pressure differential to push fish from one end to the other.  This tube is known as the Whooshh fish transport system (also referred to as a salmon or fish cannon) developed by Whooshh Innovations of Washington St...
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Physical Modeling of Sediment Transport and Deposition

Physical Modeling of Sediment Transport and Deposition

To help predict the effect of channel modifications on sediment transport and deposition, engineers have long used scaled physical models.  If used properly, modeling can provide very helpful information for resolving sediment problems at riverine water intakes.  Some recent advances in physical modeling of sediment transport at Alden have improved model fidelity, and helped reduce  the risk of building expensive solutions that do not work. A more comprehensive version of this ar...
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Fish Passage on the Connecticut River

Fish Passage on the Connecticut River

Holyoke Gas and Electric (HG&E) generates electric power at the Hadley Falls Station on the Connecticut River using two hydroelectric units with a total installed capacity of approximately 31 megawatts.  The first turbine was constructed in 1951 and is known as Hadley Unit 1.  The second turbine, known as Hadley Unit 2, was constructed in 1983.  Holyoke Dam impounds water for the Hadley Falls Station and several other generating stations on the Holyoke canal system.  It i...
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Continuing Work on Ensuring Emergency Cooling System Safety for Nuclear Power Plants

Continuing Work on Ensuring Emergency Cooling System Safety for Nuclear Power Plants

Safety of Emergency Core Cooling Systems (ECCS) has been a focus area for Alden since the 1980’s.  Head loss in strainers filtering debris out of the water that collects in containment, which is re-used to cool the reactor core during an accident, gained particular attention in 1992.  At this time, there was an incident at the Barsebäck boiling water reactor (BWR) power plant in Sweden, in which mineral wool was dislodged from piping, mixed with sludge from the suppression p...
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